Imitrex (Sumatriptan) 100 Mg

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Sumatriptan is used to treat migraines. It helps to relieve headache, pain, and other migraine symptoms (including nauseavomiting, sensitivity to light/sound). Prompt treatment helps you return to your normal routine and may decrease your need for other pain medications. Sumatriptan belongs to a class of drugs known as triptans. It affects a certain natural substance (serotonin) that causes narrowing of blood vessels in the brain. It may also relieve pain by affecting certain nerves in the brain.

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Imitrex (Sumatriptan) 100 Mg

Discription

The recommended dose of Imitrex tablets is 25 mg, 50 mg, or 100 mg. Doses of 50 mg and 100 mg may provide a greater effect than the 25-mg dose, but doses of 100 mg may not provide a greater effect than the 50-mg dose. Higher doses may have a greater risk of adverse reactions [see Clinical Studies (14)].If the migraine has not resolved by 2 hours after taking IMITREX tablets, or returns after a transient improvement, a second dose may be administered at least 2 hours after the first dose. The maximum daily dose is 200 mg in a 24-hour period.

Side Effects

Imitrex is the brand name for sumatriptan, a prescription medicine used to treat migraine headaches in adults.Imitrex is best taken as soon as the headache pain begins – not before, even if there are warning signs like aura (sensory or visual disturbances). It’s for migraine with or without aura. Imitrex is a serotonin receptor agonist. It works by narrowing blood vessels in the brain stem and reducing factors that can trigger nausea, light sensitivity, and other migraine symptoms.

GlaxoSmithKline makes Imitrex, which the Food and Drug Administration (FDA) first approved in 1992 as an injectable. Imitrex in tablet form was approved in 1995 and the nasal spray was approved in 1997.Generic forms became available by 2009. Many manufacturers offer generic sumatriptan, includingTeva, Sandoz, Mylan, and other companies.

In 2013, the FDA approved a sumatriptan transdermal skin patch, Zecuity. It was manufactured by NuPathe, now part of Teva. As of October 2014, Zecuity was not yet available in pharmacies.

Imitrex is a serotonin (5-HT1B/1D) receptor agonist (triptan) indicated for acute treatment of migraine with or without aura in adults. (1)

Limitations of Use

•Use only if a clear diagnosis of migraine headache has been established. (1)
•Not indicated for the prophylactic therapy of migraine attacks. (1)
•Not indicated for the treatment of cluster headache. (1)

DOSAGE

•Single dose of 25- mg, 50-mg, or 100-mg tablet. (2.1)
•A second dose should only be considered if some response to the first dose was observed. Separate doses by at least 2 hours. (2.1)
•Maximum dose in a 24-hour period: 200 mg. (2.1)
•Maximum single dose should not exceed 50 mg in patients with mild to moderate hepatic impairment. (2.2)

DOSAGE FORMS AND STRENGTHS

Tablets: 25 mg, 50 mg, and 100 mg (3)

CONTRAINDICATIONS

•History of coronary artery disease or coronary artery vasospasm (4)
•Wolff-Parkinson-White syndrome or other cardiac accessory conduction pathway disorders (4)
•History of stroke, transient ischemic attack, or hemiplegic or basilar migraine (4)
•Peripheral vascular disease (4)
•Ischemic bowel disease (4)
•Uncontrolled hypertension (4)
•Recent (within 24 hours) use of another 5-HT1 agonist (e.g., another triptan) or of an ergotamine-containing medication (4)
•Concurrent or recent (past 2 weeks) use of monoamine oxidase-A inhibitor (4)
•Hypersensitivity to IMITREX (angioedema and anaphylaxis seen) (4)
•Severe hepatic impairment (4)

WARNINGS AND PRECAUTIONS

•Myocardial ischemia/infarction and Prinzmetal’s angina: Perform cardiac evaluation in patients with multiple cardiovascular risk factors. (5.1)
•Arrhythmias: Discontinue IMITREX if occurs. (5.2)
•Chest/throat/neck/jaw pain, tightness, pressure, or heaviness: Generally not associated with myocardial ischemia; evaluate for coronary artery disease in patients at high risk. (5.3)
•Cerebral hemorrhage, subarachnoid hemorrhage, and stroke: Discontinue IMITREX if occurs. (5.4)
•Gastrointestinal ischemic reactions and peripheral vasospastic reactions: Discontinue IMITREX if occurs. (5.5)
•Medication overuse headache: Detoxification may be necessary. (5.6)
•Serotonin syndrome: Discontinue IMITREX if occurs. (5.7)
•Seizures: Use with caution in patients with epilepsy or a lowered seizure threshold

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Imitrex (Sumatriptan) 100 Mg

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